KR2250 is an investigational cholesterol-lowering agent. KR2250 has a high molecular weight and is extensively bound to albumin. KR2250 will have a(n) ___ apparent volume of distribution (Vd).

A. High
B. Low
C. Extremely high
D. Normal

CHECK ANSWER

The correct answer is C. Extremely high

Because of its high molecular weight and high protein binding, KR2250 will be effectively
trapped within the plasma (vascular) compartment and will have a low apparent volume of distribution.