A 40-year-old male patient (70 kg) was recently diagnosed with infection involving methicillin-resistant S.aureus. He received 2000 mg of vancomycin as an IV loading dose. The peak plasma concentration of vancomycin was 28.5 mg/L. The apparent volume of distribution is:

October 19, 2025

A. 1 L/kg
B. 7 L/kg
C. 10 L/kg
D. 14 L/kg

CHECK ANSWER

The correct answer is A. 1 L/kg

Vd = dose/C = 2000 mg/28.5 mg/L = 70.1 L. Because the patient is 70 kg, the apparent
volume of distribution in L/kg will be approximately 1 L/kg (70.1 L/70 kg).

A 40-year-old male patient (70 kg) was recently diagnosed with infection involving methicillin-resistant S.aureus. He received 2000 mg of vancomycin as an IV loading dose. The peak plasma concentration of vancomycin was 28.5 mg/L. The apparent volume of distribution is:

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